Design

• Compact, integrated skid installation of vessel, control unit and supply technologies

• Engineered for reproducible sterility by design

• Complex production plants with seed- and main-fermenters, media supply vessels,

• CIP/SIP-supply units, steam generators – all in closed connection and fully automated

• GMP-compliant design with all options for qualified and validated operation

  Materials

• Certified stainless steel pressure vessels 1.4435/1.4571 or other

• Stainless steel pipes and frames

• All media contact parts chemically resistant and biologically inert

  Automations

• 19”-touchscreen with intuitive menu design

• Superior trend display with data analysis and visualization capabilities

• Self-explanatory sequence editor and easy-to-handle control loops

• Fully automated and logged sterilization sequences

• Bidirectional OPC-communication with SCADA-software

• License-free remote access with VNC-client via Ethernet

  Media Handling

• Up to 10 peristaltic pumps

• Free sizing of all pumps

• Free pump purpose allocation

• Independent drive for each pump

• Digital or analogue drive selection

• External pumps from lab to scale

  Gas Handling

• Up to 6 mass flow controllers

• Rotameters for manual flow control

• Up to 4 gasses

• Input pressure reducers

• Complex gassing regimes

• High cell density cultivation possible

  Measures (W x H x D)

• 1,300 x 1,900 x 800 mm

  Media Handling

• 5 x peristaltic pumps

• 3 x digital, 2 x analogue

• For corrective media & harvest/feed

• 2 x AO for external pump

  Gas Handling

• 1 x MFC for oxygen

• 1 x magnetic valve for air/nitrogen

• 1 x sum flow rotameter

• 1 x microsparger

  Sensors

• 1 x temperature in medium

• 1 x pH in medium

• 1 x pressure in exhaust line

• 1 x pO2 in medium

• 1 x level or foam detection

• 1 x foam in exhaust line

  Stirrer

• Top drive

• Powerful servo drive

• 3 x Rushton impellers

• Continuous speed control 0...1,200 rpm

  Equipment

• Integrated steam generator 50 kg/h