• Medium screen format for clarified solutions, low to medium viscosity, and final concentrations < 30% (300 mg/mL)
• Suspended screen format for:
        Solutions containing particles, cells, and cell debris in solution
        Solutions that are highly viscous and highly concentrated

Supor polyethersulfone (PES) membrane cassettes are optimized for microfiltration applications, easily scaled and suited to a broad range of cleaning options.

Pall’s tangential flow filtration (TFF) cassettes with Supor membrane are intended for microfiltration (MF) applications. The cassette contains a Supor microfiltration-optimized polyethersulfone membrane.

They are available in two formats – Centramate and Centrasette II cassettes – and in a range of pore sizes from 0.1 μm to 0.65 μm to meet most application requirements.

Proven Supor TFF Membrane

Supor TFF membrane is a modified polyethersulfone membrane with a uniform depth structure. The membrane is optimized for microfiltration applications in TFF including harvest, concentration and clarification of cell cultures and fermentation broths. Supor TFF membranes are ideal for applications including harvesting bacterial, mammalian, and insect cells; separating red blood cells from hemoglobin; and for clarifying yeast broth and bacterial lysates.

Features and Benefits

• Low non-specific adsorption due to its hydrophilic chemistry which leads to higher product yields
• Wide range of membrane pore sizes to optimize the process
• Compatible with acids, bases, oxidizing agents and variety of other cleaning agents to fit different application needs

Cassette Channel Configurations

Pall’s microfiltration cassettes with Supor Membrane are available in medium and suspended screen channel formats to best meet the specific requirements of each application.

Table 1 - Selection criteria for a cassette channel configuration

Channel Configuration	Selection Criteria
Medium screen	Clarified solutions; low – medium viscosity Final concentration < 30% (300 mg/mL)
Suspended screen / open channel	Particles/cells/cell debris in solution High viscosity

Table 2 - Materials of construction

Membrane	Supor microfiltration-optimized polyethersulfone
Encapsulant	Polyurethane
Screens	Polyester
Spacers	Polyolefin/PES

Cassettes pass current USP Biological Safety Tests for Class VI Plastics at 70 °C.

Storage Agents

Pall’s microfiltration cassettes with Supor Membrane are shipped wet, in liquid containing a humectant and bactericidal storage solution. This solution consists of 15 – 20% glycerin, and 0.05 – 0.1% sodium azide.

The storage solution must be removed and the cassette flushed well with water prior to use to prevent product contamination.

Traceability

Each microfiltration cassette with Supor membrane has a unique serial number for full traceability.

Each cassette is supplied with:

• Certificate of quality
• Membrane cassette care and use procedures
• Material safety data sheet (MSDS) for cassette preservative
• Two platinum-cured silicon gaskets